Rams vs. 49ers

A primetime battle on Monday Night Football features 

the Los Angeles Rams (2-1) hosting the San Francisco 49ers (1-2). 

It will be a battle between 2 incursive masterminds in Kyle Shanahan and Sean McVay.

McVay is 4-7 against Shanahan, and the 49ers will be without star left tackle Trent Williams (high ankle sprain).

Both teams are 1-2 against the spread this season.

Kickoff from Levi's Stadium in Santa Clara, California, is set for 8:15 p.m. ET 

The San Francisco Caesars are favored by two points in the latest Rams vs. 49ers odds from Sportsbook and the over/under is 42.5.

Any 49ers vs. Before picking the Rams, you need to check NFL prediction

And betting tips from the SportsLine projection model.